I have to agree about changing the location of the bathroom; looks like a big eye-sore in middle of room and blocks full layout view. However, something nobody has mentioned - if you plan to run your trains around the loops a lot, the last thing you want is a double-slip switch on that main line. No matter who makes it or how carefully it is installed, running through that switch a speed will just be one headache after another. Stopping that yard lead from crossing the inner mainline will solve the potential derailment problem as well.
Chuck