For many of us here that is the elephant in the room. My train-room and her sewing-room are on the second floor. She suffered a ruptured tendon and torn tendon in her foot and has not been able to negotiate the stairs. If/when that sort of issue becomes permanent for either of us we will resort to a stair-elevator. This was part of the plan when we bought this house.
If I were building a dedicated building I would plan for such [possible] eventualities. Of course, I'm not averse to porta-pottys or peeing in a jar if that's what it takes to keep on keeping on.
Lew