I'd be concerned about the far side in that design - you have 6" center to center on the side with the crossovers, but only 4" center to center on the other side since you've functionally got an inner 48" loop and an outer 58" loop. Any loco with significant overhang on 048 curves running on the inner loop will probably swipe the train running on the outer loop. Slapping an additional 1 3/4" straight in the short sides of the outer loop will bring you to almost 6" center to center on the far side as well.
I'd also recommend putting a short straight section between the curves and the switches on the outer loop, even if it's just a short fitter. I had an issue on my layout where one of my locos would derail when backing through an 048 curve straight into the diverging route of an 060 switch (in the same direction as the curve) - adding a 1 3/4" straight between the curve and the switch fixed it.
