Many times and I've hit almost all of the options. Pullman berth after I was inducted in 1964 on the way to South Carolina for basic, Montreal to NYC on the D&H/NYC, with family to Chicago with adjoining bedrooms opened during the day into one big room, slept sitting up to Chicago once on Amtrak. More recently I've been traveling on the Silver Star to FL (was a fine trip when they still had the diner) both in roomettes by myself and later with my wife now we reserve the handicapped bedroom. As Joe said it does have an upper berth but has an enclosed toilet and a lot of room.
Now that I think about it I've actually done a wide variety of long distance trains (and for my sins I even commuted on the LIRR in the late 60's).