This question comes up so frequently I have about concluded Rich should create a new forum just so people can discuss whether to keep boxes.
In any event; I've kept all of mine for rolling stock and engines. I've had to relocate multiple times because of my job and having the boxes has served to protect everything during each of our moves.
Ultimately the decision to keep or discard is a personal choice and largely determined by whether you have the storage space to hold the boxes.
Curt