I have tried to run scale wheels on my layout as I really do like the look of the scale wheels.
That said, as others have pointed out . . . switches are a problem. I just tried HW's styrene-strips-on-the-guard-rail solution on one of my Ross switches. Big improvement for sure on the most troublesome areas but I'm not entirely there yet. Also my trackwork is not up to snuff as I have occasional derailments on other sections too, where no switches are involved. My switched loop is all O-72.
On my outer loop, which is switchless and min. radius O-80, no problem with the scale wheels. Ross track, BTW.
But, illuminated pass. cars seems a whole other thing! My scale wheel cars are all freight and none are long.