I'll assume home layout rahter than commercial display.
My vote is for Brooks Stover"s S-Scale Buffalo Creek and Gauley.
Brooks has done a great job of capturing the flavor of the prototype and its operations. The scenery and detail is simply very well done. If you want to see some photos search for the "Buffalo Creek & Gauley" and go to the webstie. Brooks maintains a site for the prototype history and also has photos of his layout.