How about talking stations? The announcer/conductor calls out some cities, e.g. something like... "New York Central train loading on track 7, Chicago to New York and points in between...All aboard".
The A.F. talking "City Station" I have is too incomplete to know if there is a city name attached to it. Lionel did do a repop of it a few years ago though. You could search Da Bay for talking station replacement sounds and review quite a few of those old recordings made by various mfgs.. They really have a decent selection, some rare I guess.
I also recall some city named stickers for one of the plastic stations signs, but don't recall the whole station or who made it. (A.F. or Plastiville most likely, even though I never owned any A.F. trains)
As a kid, I assumed most cars were named after a city it stopped in.
I'm not sure if it was ever done that that way at all, but it kept me content with variety.
I eventually outgrew any want or need for realism like that. Today, I stop at the Moon station, on the way to Mars if it suits my mood (a Looney Toones/Marvin the Martian layout with a Marx moonscape centerpiece and earth globe mounted on a floor lamp stand, set just off the side of the layout.)
One stop, not on a sign, but always an option for me, is "A Stop in Willoughby; one of my favortite Twilight Zone episodes.