First of all, I do often wear gloves when handling my MTH tinplate. That way you don't have clean the fingerprints. But yes, I use DCS to operate all my Standard Gauge tinplate, O Gauge tinplate, and modern O Gauge trains.
In fact, I even programmed my Legacy and 3rd Rail engines into the DCS Remote so I control them via DCS also. I'm definitely not what you'd call an advanced user though. I just control the throttle, smoke, horn, whistle, the occasional coupler, etc. Otherwise, I watch them run!
As for controlling tinplate with DCS, I find it absolutely necessary because I like to turn the volume on/off or the turn the smoke on/off depending who walks in the room. It's especially helpful at Christmas time. Therefore, I never operate conventionally.
