I have the ECOS 50200 and just tried it out with an MTH SD70Mac set to DCC 3 rail--works great (just starting up an O gauge layout after years of HO and N). I use my ECOS for my N scale layout and it is such a nice controller (and given its expense) I wanted to see if I could use it for my O scale layout--only thing I need to do now is get a power booster so I can run the O gauge at one voltage and the N at another--Of course I need to decide between the 4amp or 8 amp booster. Initial testing shows the SD70 pulls about 0.35amps, and the passenger cars (5 of them) pull 1.2 amps. I will likely also run an MTH GP40 and a switcher too--with automating switches, I figure 8 amps to be safe and allow for growth, but the stock 4 amp power supply would definetly work.
I have used DCS in the past (for an HO layout) but I still prefer the ECOS system--having my graphical display of the layout to throw switches plus dual throttles, and the multi function for each throttle just makes it very easy to control multiple locomotives. I figure I will use one throttle for the N layout and one for the O.