Nick,
Ok, the 6 switches for the crossovers and r-loops are now 4 - O42 and 2-O42 wyes. It doesn't mess with your aisle a lot. Move some of your scenery spots and perhaps make a trolley loop where the O36 was. O31/32 will fit nicely or Streets with O21.
It only takes a small amount of table adjusting. You need to work on the bridge angle in front of the door to match the track angle.
I would go with the mixed O42-O54 around the pillar and O54-O63 around that for the O42 mainline.
This is on 4.5" centers set by the 11° crossovers for the main.
Whaddya think?
The pencil and paper are still good. Don't sell yourself short. Look at your result. Nice design for the space. The software just permits a pre-build without doing it.