If one has the patience for it, S is certainly an option.
Here's some Santa Fe that's been available.
MTH (ex SHS) F3's, S-Helper F7's (unfortunately not currently available,) AM SF Budd cars in the background.
American Models GP9's (still available) w/details added.
American Models 2900 class 4-8-4's (Left, dolled up a little. Right, straight from the box. (Still available with scale wheels.)
Plus AM has a Baldwin S12 in zebra stripe and E8's available. Both S-Helper and MTH offered EMD switchers in Santa Fe