My 2 cents, regarding the OP's question.
"Yes", if you are willing to accept the pretty limited options.
Like most everyone, I feel 1/64 is the "perfect" size, so I dabble.
I've been able to collect some vintage "scale" rolling stock, and since my Flyer 300 and 310 run SO well, I picked up some spare tenders and converted them to Kadee couplers, so I can run these together.
Here's the 300 coupled to a Mid Gage boxcar:
Not overly interesting, I know, but I have fun doing stuff like this...
Mark in Oregon