When we built our house, I had two 20 amp circuits put in the basement (train room). Each circuit is controlled by its own 20 amp wall switch near the stairs. I also have my transformers plugged into surge protectors.
I used to turn off the surge protectors and the wall switches, but now just the wall switches. The wall switches are hard to miss and easy to check when I leave the basement.
Having these “master” switches gives me a good level of comfort that there is no power to the layout when I leave the room.