Looks good - you might want to consider adding a few sidings at a couple of locations on the layout, especially the industry area. It will also help as storage for your engines and rolling stock so you don't have to continually take them on/off the layout when you want to use them.
Depending on what track system you plan on using, most have a little flex and wiggle room so that the sections can be made to physically connect when you actually lay the track out, even if the track plan shows them slightly off.
