My two previous, much smaller layouts, where running oriented with multiple loops and only a few siding to holds trains waiting their turn to be run. I enjoyed running while I worked on other parts of the layout, but at the same time it did get old after awhile. I redid some of the sidings on my last layout for some industries and switching operations and I found I also enjoyed that.
My in-progress layout is much bigger and still has three loops for running. But it also has some industries, a power station-coal mine companion setup, ice track, passenger station with tracks to pickup/drop off diners/RPOs, and a usable yard with a yard lead track. It also has a hidden storage yard.
I guess I need to get this up and running and see which type of operation I like best.