The reason I asked about the open spaces is to truly go around the room, you'll have to accommodate access to those spaces. I did a 1/4 around the room for that reason. I had too many openings and access requirements for me to be able to do a true around-the-room configuration. The more thinking you do about what you want and how to access all the spaces now will pay big dividends as you build. FWIW, I started with Mianne benchwork as well, but then a real carpentry expert came along and convinced me to get fancy with the benchwork on top of the Mianne.
Mine in process layout is a large folded dogbone on two levels, and it has a few extra loops off the large mainline. The big box sticking up is the Mianne power lift-bridge for access to the inside, I'm too old to crawl under benchwork as a regular habit. Obviously, not finished yet, but working on it.