Depends. If you have cats or brats...a.k.a., destructive forces...roaming about, and you wouldn't consider your polytropolis to be 'collectable'......I'd try moo-glue: Elmers. It'll help the structures to withstand some tremors, invasions of evil-doers, and bumps in the night.
Also, there's Plasticville, and then there's Plasticville. IOW, they're still making the stuff. Newer P-ville is not of the same polymer, hardly considered "collectible". If you have older, bought-new-been-in-the-family-since-God-knows-when P-ville that still has marks of sentimentality...like spray-on 'snow', chipped corners, hot bulb warpage, candy-cane residue from sticky 'ittle fingers, etc., etc....then moo-glue would be my choice, anyway.
If you're a military family, I'd probably forget the glue....you're probably going to have to pack up and move...again.
Lucas Gudinov