I had a feeling it would be an unwieldy and downright absurd vehicle. But, with the right-sized frame and strong enough wheels, would it work?
No.
Forget practicality, I'm just wondering if it can even be done.
No.
I know this is an absurd question, but when I heard about racing cars using airplane engines,
What size airplane engine and in what size/class race car?
and one that uses a boat engine,
Again, what size boat engine in what size/class race car? On the other hand, look what the NHRA Top Fuel and Funny Car folks have accomplished with a 500 cubic inch Hemi engine, based off the original Chrysler 426 Hemi. They now force upwards of 10,000HP for a bit more than three seconds out of those 500 cubic inches.
this question came to mind.