This is what I have done for several years
To minimize dust in the layout room: HEPA AIR PURIFIER. Model 50250-S True HEPA Air Purifier, I have two of them
To prevent the dust that does get through from landing on your trains:, cars, trucks, and any hard surfaces: STATICIDE
To blow off any residual dust: AEROSOL DUSTER (sometimes needs a soft brush for encouragement)