If I may weigh in here...
I agree with Sarah (to a point): if one has the $ and the time and space, it really doesn't matter what scale/gauge you choose. 
Having said that, Dave's strategy (small switching layout) might be all he has room for. If you look at the typical European approach (where space is usually at a premium), that same lack of space is what often gives raise to those wonderfully detailed scenes that are such a joy to behold,regardless of scale.
I know Protocraft offers code 125 flex track; turnouts may still have to be hand laid.
As in all things, whatever works for you is the "best approach"... 
Mark in Oregon
