@Casey Jones hopefully Don will give you a definite answer. But most of these newer wireless systems are designed for low-current DC "can" motors. All postwar Lionel locos have universal series-wound motors. Although universal motors will run on DC, current draw is pretty high (up to 2.5 amps per motor.) It might also be necessary to separate the motor ground from the chassis ground. In a metal-bodied steam loco designed for use on 3-rail track, that could be very difficult.
The only command control solution I know of that's specifically designed for postwar Lionel, is the Electric Rail Road (ERR) AC Commander.