My situation is an odd one. If I were starting over, say five years ago, I would probably have gone 2-rail. Some of my 2-rail colleagues have literally said I'm a 2-railer but just don't know it yet. What is attractive about 3-rail is the big power/sharp curve capability inherent in all of the equipment.
The irony is that all of my home layout designs, with a couple of exceptions are based around a minimum 48" radius, even though they're designed to be able to support "legacy (3-rail) equipment. I've figured out hybrid wiring and sensing that supports both 2-rail and 3-rail.
From my research and preliminary testing, there's really no big advantage to 3-rail over 2-rail save the absence of reverse loop/wye issues. It really comes down to whether you can life with swinging pilots, larger couplers and a third rail in the middle.