You can certainly swap smoke units, it requires a bit of rewiring. More than one person has taken the smart smoke with the troublesome regulator out and put in a standard smoke unit. FWIW, if you ever run across a 6 ohm resistor, swap it for an 8 ohm resistor. Lionel suggested that change years ago, the 6 ohm resistor was too hard on the regulators and was killing them regularly. Even the 8 ohm ones are hard on regulators, I have a batch of regulators on order right now, and two waiting in the corner for the replacements.
I've put Super-Chuffers in all sorts of locomotives, including those with and without various incarnations of smart smoke, and with and without regulators.