Our modular club layout uses steel studs and we run TMCC without any signalling issues at all. Our layout is 36 feet by 16 feet, as best that I recall. Since it gets hauled around to the various shows in the San Francisco Bay Area, it get some pretty rough handling. But the guys built it almost bullet proof. It has withstand the time, I think is't about 15 years old.
I only joined the group about 3 years ago, a great bunch of guys.
Here are some photos of the layout.
The GN engine is mine, we use green material to hide the legs, not the control panel in the back attached to the metal stud frame.
Here's a shot of the inside of the layout with one of 3 control panels.
Here is a better photo of the guys removing some of the modules. Wood on the end, steel on the sides.