Jeffrey, Seeing Carl's captures, puts the layout plan into perspective for me. For that space, I think it is just about right. A tweek here or there by folks who have a better eye than me, and some more tweeks while building, and I think you will have an interesting layout with many scenic and industrial possibilities.
I tried On30 as a step to larger trains and structures from the HO I had modeled for years. This was just of a couple of modules, and no scenery, just a few O scale buildings. The On30 trains by Bachmanm run and look great, but I decided I didn't want the slow pace of narrow gauge. A full size branch line in the Appalachians is more to my liking. I then found O gauge 3-rail, and knew that was what I wanted. You can see my plan development on my topic that has a link in my signature line. This is strictly my journey and what has suited me. Your experience and interests will surely vary.
Again, I think you have a good plan from what I see on the captures.