Jay - I keep thinking I do not want or need a huge layout, but when I start planning - 072s and larger take up an awful lot of real estate. I'll have to lay it out on scarm, but passenger platforms should be at least 8 feet wide (~2 inches scale) . So each track platform combination should need 6 or 7 inches. 8 tracks would be about 4 feet wide. Then for the crazy stuff. That would give me an area 4 x 10 to layout a town/city. An elevated track (common in Chicago) for my Subway set could then run around the city. At street level it might be fun to install a 2 Rail street car line. Now I have to put on Supertramp's "Dreamer" song.
Seth - the buildings are looking good. I assume you will tone down the mortar lines around the windows? I've posted this photo before - I tried adding several brick colors to this building and am reasonably happy with how it turned out. Noticed some of that on one of your buildings.