Glad you're still going strong, Dewey!
Oh, yes, the pain-to-gain ratio, applicable in terms of both layout construction and maintenance. I consider > 200 sq. ft. 'large.' My previous layout was 35 ft. long by about 6 ft. deep, with 4 levels of track in front and back, and winding throughout, in a relative clean/dry but with some dust basement. It became a chore to keep clean, dust on track becomes grime over short periods of time as wheels compress and mix with oils because much of the track was difficult to reach/access.
New layout is 15 ft. by 9 ft oval-shaped island style layout in basement with less dust and equally dry as previous and most track is easy to reach, and is much more comfortable. If I expand to a perimeter layout, all track will be easy to reach as well.