So many opinions it's challenging to figure out what's what. Can someone say definitively what curve diameters (or use radii) an O-scale 2-rail Big Boy or Challenger requires? If the consensus is that they need >120" diameters (60" radii) then I think we know the answer to the OP's question. However, it's not readily apparent to O-gaugers that by using an "around the room" layout configuration large diameters can be incorporated fairly easily.
Arguably, these are the two most popular models in 3-rail...at least given by how many times Lionel and MTH re-release them, lol.