'Yes' would very much depend on what was proposed. Some of the 'tougher' sets from 1956-59 that have not been already reissued by Lionel might draw in more takers.
If it was a prewar 'Chicago' Flyer tinplate set, yes, I could be very interested. At this time, there are no reproductions of any Flyer O gauge tinplate at all. But unfortunately, there is no existing tooling to serve as a basis for such an offering.
Bob Bubeck
PS: I have been informed by the folks at Lionel that the Defender set is still slated for production.