The most common failure point for solid state equipment is at the moment of power turn on. Keeping that in mind…
I have two PCs (an OGR machine and a personal machine) and a MAC (for video editing) in my home office. There are also fifteen hard drives, three printers, three Synology NAS backup drive arrays, two scanners, a 16-channel audio mixer, an audio system, and a total of seven monitors. All that stuff has been turned on and running 24/7 for YEARS. They were on for years at the OGR office in Poland, Ohio, and have now been on 24/7 here at the house in Columbus since we moved here seven years ago. I never turn them off.
I have had zero problems with any of the equipment. The two PCs were purchased in 2002 when OGR Publishing, Inc. was formed. That means they are 21 years old! I’ve replaced disc drives and added RAM over the years, but that’s it. I just replaced a 34-year old Mackie 1604 audio mixer because it had developed a 120 Hz hum due to failing filter caps. I got my money's worth out of that thing!
If I had a TIU/WIU, etc. I would leave them on 24/7, too.